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Large Area Fabrication of Leaning Silicon Nanopillars for Surface Enhanced Raman Spectroscopy
Application: Fabrication of SERS substrates
Citation: M. S. Schmidt, J. Hübner, and A. Boisen, Adv. Mater. 2012, 24, OP11-OP18
Summary: The paper presents a simple method for producing flexible, free-standing noble metal nanopillar structures for SERS applications. The nanopillars are fabricated from silicon and the resulting SERS substrates exhibit a remarkably large enhancement of the Raman signal due to analyte trapping.
Surface-Enhanced Raman Spectroscopy Based Quantitative Bioassay on Aptamer-Functionalized Nanopillars Using Large-Area Raman Mapping
Application: Detection of TAMRA-labeled vasopressin molecules
Citation: J. Yang, M. Palla, F. G. Bosco, T. Rindzevicius, T. S. Alstrøm, M. S. Schmidt, A. Boisen, J. Ju, and Q. Lin, ACS NANO 2013, 7, 5350-5359.
Summary: In this study, TAMRA-labeled vasopressin molecules in the picomolar regime (1 pM to 1 nM) are specifically captured by aptamers on the gold nanopillar SERS substrate and monitored by using an automated SERS signal mapping technique.
A Microfluidic surface enhanced Raman spectroscopy biosensor using aptamer functionalized nanopillars
Application: Detection of vasopressin molecules employing a microfluidics SERS set-up
Citation: J. Yang, M. Palla, F. G. Bosco, M. S. Schmidt, T. Rindzevicius, A. Boisen, J. Ju, Q. Lin, IEEE Transducers, 2013, 1799-1802
Summary: In a temperature controlled microchamber, aptamers immobilized on the gold nanopillar surface specifically recognize target molecules. The device demonstrates quatitative detection of vasopressin in the picomolar regime.
Synthesis and characterization of covalent diphenylalanine nanotube-folic acid conjugates
Application: SERS detection of folic acid (cancer related applications)
Citation: J. J. Castillo, T. Rindzevicius, K. Wu, M. S. Schmidt, K. A. Janik, A. Boisen, W. Svendsen, N. Rozlosnik, J. Castillo-León, J. Nanopart. Res., 2014, 16, 1-8
Summary: The paper presents a synthesis procedure to form diphenylalanine (PNT) and folic acid (FA) conjugates. The PNT-FA conjugate is a promising candidate for applications in the detection and diagnosis of cancer or tropical diseases such as leishmaniasis and as a carrier nanosystem delivering drugs to malignant tumors that overexpress folate receptors.
Non-labeling multiplex surface enhanced Raman scattering (SERS) detection of volatile organic compounds (VOCs)
Application: SERS detection of VOCs
Citation: C. L. Wonga, U.S. Dinisha, M. S. Schmidt, M. Olivoa, Anal. Chim. Acta, 2014, 844, 54-60
Summary: In this paper, we report multiplex SERS based VOCs detection with a leaning nano-pillar substrate. The VOCs analyte molecules adsorbed at the tips of the nano-pillars produced SERS signal due to the field enhancement occurring at the localized surface plasmon hot spots between adjacent leaning nano-pillars.
Wafer-Scale Leaning Silver Nanopillars for Molecular Detection at Ultra-Low Concentrations
Application: Wafer-scale SERS substrates
Citation: K. Wu, T. Rindzevicius, M. S. Schmidt, K. Bo Mogensen, A. Hakonen, and A. Boisen, J. Phys. Chem. C, 2015, 119, 2053-2062
Summary: Wafer-scale surface-enhanced Raman scattering (SERS) substrates fabricated using maskless lithography are important for scalable production targets. Large-area, leaning silver-capped silicon nanopillar (Ag NP) structures suitable for SERS molecular detection at extremely low analyte concentrations are presented.
Plasmon resonances of Ag capped Si nanopillars fabricated using mask-less lithography
Application: Optical properties of Ag-capped Si nanopillar structures
Citation: K. Wu, T. Rindzevicius, M. S. Schmidt, K. Bo Mogensen, S. Xiao, and A. Boisen, OPTICS EXPRESS, 2015, 23, 12965-12978
Summary: Localized surface plasmon resonances (LSPR) and plasmon coupling in Ag capped Si nanopillar structures are studied using 3D FEM simulations and dark-field scattering microscopy.
Silver-capped silicon nanopillar platforms for adsorption studies of folic acid using surface enhanced Raman spectroscopy and density functional theory
Application: SERS and DFT of folic acid molecule
Citation: J. J. Castillo, T. Rindzevicius, K. Wu, C. E. Rozo, M. S. Schmidt, and A. Boisen, J. Raman Spectrosc., 2015, 46, 1087-1094
Summary: The paper presents a study of the adsorption of FA on silver-capped silicon nanopillar substrates employing surface enhanced Raman scattering spectroscopy and density functional theory calculations.
Towards quantitative SERS detection of hydrogen cyanide at ppb level for human breath analysis
Application: SERS-based detection of HCN
Citation: R. K. Lauridsen, T. Rindzevicius, S. Molin, H. K. Johansen, R. W. Berg, T. S. Alstrøm, K. Almdal, F. Larsen, M. S. Schmidt, and A. Boisen, Sensing and Bio-Sensing Research, 2015, 5, 84-89
Summary: Lung infections with Pseudomonas aeruginosa (PA) is the most common cause of morbidity and mortality in cystic fibrosis (CF) patients. Hydrogen cyanide (HCN) at ppb level has been reported to be a PA biomarker. For early PA detection in CF children not yet chronically lung infected a non-invasive SERS-based breath nanosensor is being developed.
Mathematical Model for Biomolecular Quantification Using Large-Area Surface-Enhanced Raman Spectroscopy Mapping
Application: SERS signal mapping: biomolecular quantification
Citation: M. Palla, F. G. Bosco, J. Yang, T. Rindzevicius, T. S. Alstrøm, M. S. Schmidt, Q. Lin, J. Ju, A. Boisen, RSC Advances, 2015, 5, 85845-85853
Summary: A mathematical model to predict experimental SERS signal intensity distributions of target molecules on receptor functionalized nanopillar substrates for biomolecular quantification is presented. Our general theoretical framework agrees with the experimental data particularly well in the picomolar concentration regimes.
Detection of nerve gases using surface-enhanced Raman scattering substrates with high droplet adhesion
Application: SERS-based detection of two nerve gases, VX and Tabun
Citation: A. Hakonen, T. Rindzevicius, M. S. Schmidt, P. O. Andersson, L. Juhlin, M. Svedendahl, A. Boisen, and M. Käll, Nanoscale, 2016, 8, 1305-1308
Summary:Here we demonstrate that surface-enhanced Raman scattering (SERS) can be used for sensitive detection of femtomol quantities of two nerve gases, VX and Tabun, using a handheld Raman device and SERS substrates consisting of flexible gold-covered Si nanopillars.